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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 34
Species	Homo sapiens (Human)
Gene	GPR34
Synonym	GPR34
Disease	N/A
Length	381
Amino acid sequence	MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
UniProt	Q9UPC5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UPC5
3D structure model	This predicted structure model is from GPCR-EXP Q9UPC5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3562165
IUPHAR	101
DrugBank	N/A

Ligand

Name	CHEMBL3577145
Molecular formula	C22H44NO9P
IUPAC name	(2S)-2-amino-3-[[(2R)-3-hexadecanoyloxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxypropanoic acid
Molecular weight	497.566
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	2.0
Synonyms	BDBM50096353 SCHEMBL13863416 L-Serine, 2-hydroxy-3-[(1-oxohexadecyl)oxy]propyl hydrogen phosphate (ester), sodium salt, (R)- 1-palmitoyl-sn-glycero-3-phospho-l-serine Palmitoyllysophosphatidylserine ZINC85604003 LMGP03050002 PS(16:0/0:0) 1-hexadecanoyl-sn-glycero-3-phosphoserine LPS(16:0) [ Show all ]
Inchi Key	XIVOBOJQPNEUSC-UXHICEINSA-N
Inchi ID	InChI=1S/C22H44NO9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(25)30-16-19(24)17-31-33(28,29)32-18-20(23)22(26)27/h19-20,24H,2-18,23H2,1H3,(H,26,27)(H,28,29)/t19-,20+/m1/s1
PubChem CID	9547100
ChEMBL	CHEMBL3577145
IUPHAR	N/A
BindingDB	50096353
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	288.0 nM	PMID25970039	BindingDB
EC50	288.4 nM	PMID25970039	ChEMBL
EC50	290.0 nM	PMID25970039	BindingDB,ChEMBL

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