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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	3-iodothyronamine
Molecular formula	C14H14INO2
IUPAC name	4-[4-(2-aminoethyl)-2-iodophenoxy]phenol
Molecular weight	355.175
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.1
Synonyms	4-(4-(2-amoethinyl)-2-iodophenoxy)phenol Phenol, 4-[4-(2-aminoethyl)-2-iodophenoxy]- BDBM50359505 ZINC13681007 4-[4-(2-aminoethyl)-2-iodophenoxy]phenol CHEMBL1182312 712349-95-6 SCHEMBL359453 CHEBI:89700 4-[4-(2-Aminoethyl)-2-iodphenoxy]phenol DTXSID80433256 AKOS028113698 T1AM [ Show all ]
Inchi Key	XIINYOJWNGOUPF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2
PubChem CID	9950514
ChEMBL	CHEMBL1182312
IUPHAR	N/A
BindingDB	50359505
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	112.0 nM	MedChemComm, (2016) 7:2:353	ChEMBL
EC50	189.0 nM	PMID26010728	BindingDB,ChEMBL

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