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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL82360
Molecular formula	C17H25ClN2O2
IUPAC name	1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-ethylpiperidin-4-yl)propan-1-one
Molecular weight	324.849
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.0
Synonyms	BDBM50213015 SCHEMBL7354794
Inchi Key	AATBBQHADVZFQY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H25ClN2O2/c1-3-20-8-6-12(7-9-20)4-5-16(21)13-10-14(18)15(19)11-17(13)22-2/h10-12H,3-9,19H2,1-2H3
PubChem CID	19081860
ChEMBL	CHEMBL82360
IUPHAR	N/A
BindingDB	50213015
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	15.85 nM	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL
EC50	16.0 nM	N/A	BindingDB
Intrinsic activity	0.61 -	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL

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