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GPCR

NameD(3) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD3
Synonymdopaminergic receptor D3
D3R
D3 receptor
dopamine D3 receptor
DiseaseUnspecified
Emesis; Gastric motility disorder
Female sexual dysfunction
Male sexual disorders
Psychotic disorders
[ Show all ]
Length400
Amino acid sequenceMASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProtP35462
Protein Data Bank3pbl
GPCR-HGmod modelP35462
3D structure modelThis structure is from PDB ID 3pbl.
BioLiPBL0191566, BL0191567
Therapeutic Target DatabaseT02551
ChEMBLCHEMBL234
IUPHAR216
DrugBankBE0000581

Ligand

NameCHEMBL211135
Molecular formulaC17H17Cl2N5
IUPAC name6-chloro-2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]imidazo[1,2-b]pyridazine
Molecular weight362.258
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.4
Synonyms6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]imidazo[1,2-b]pyridazine
BDBM50189849
Inchi KeyAGMWTWZTMQSDHF-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
PubChem CID11559581
ChEMBLCHEMBL211135
IUPHARN/A
BindingDB50189849
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki7700.0 nMPMID16789750BindingDB,ChEMBL

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