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GLASS

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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Homo sapiens (Human)
Gene	PTGER4
Synonym	Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2
Disease	Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis Osteoarthritis; Pain Pain Fracture Asthma Acute heart failure [ Show all ]
Length	488
Amino acid sequence	MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
UniProt	P35408
Protein Data Bank	5ywy, 5yhl
GPCR-HGmod model	P35408
3D structure model	This structure is from PDB ID 5ywy.
BioLiP	BL0434347, BL0434289
Therapeutic Target Database	T18876
ChEMBL	CHEMBL1836
IUPHAR	343
DrugBank	BE0003522

Ligand

Name	CHEMBL14600
Molecular formula	C19H25N5O2S
IUPAC name	(5R)-5-[(E)-3-hydroxy-4-phenylbut-1-enyl]-1-[4-(2H-tetrazol-5-ylsulfanyl)butyl]pyrrolidin-2-one
Molecular weight	387.502
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.2
Synonyms	SCHEMBL6436855 (R)-5-((E)-3-Hydroxy-4-phenyl-but-1-enyl)-1-[4-(1H-tetrazol-5-ylsulfanyl)-butyl]-pyrrolidin-2-one BDBM50125410 SCHEMBL6436853 5-[4-[(2R)-2beta-(3-Hydroxy-4-phenyl-1-butenyl)-5-oxopyrrolizino]butylthio]-1H-tetrazole
Inchi Key	CSYHDBJGSZIDDS-FNPGKKEOSA-N
Inchi ID	InChI=1S/C19H25N5O2S/c25-17(14-15-6-2-1-3-7-15)10-8-16-9-11-18(26)24(16)12-4-5-13-27-19-20-22-23-21-19/h1-3,6-8,10,16-17,25H,4-5,9,11-14H2,(H,20,21,22,23)/b10-8+/t16-,17?/m0/s1
PubChem CID	44269468
ChEMBL	CHEMBL14600
IUPHAR	N/A
BindingDB	50125410
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	243.0 nM	PMID12643927	BindingDB,ChEMBL

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