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GPCR

NameTrace amine-associated receptor 1
SpeciesMus musculus (Mouse)
GeneTaar1
SynonymTA1 receptor
TaR-1
TAR1
trace amine receptor 1
TRAR1
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProtQ923Y8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4908
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL3702012
Molecular formulaC17H22N4O
IUPAC name5-ethoxy-N-[4-[(3S)-piperidin-3-yl]phenyl]pyrimidin-2-amine
Molecular weight298.39
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.5
SynonymsUS8802673, 114
BDBM129472
SCHEMBL12610351
Inchi KeyCSVGASRBSIUPPY-CQSZACIVSA-N
Inchi IDInChI=1S/C17H22N4O/c1-2-22-16-11-19-17(20-12-16)21-15-7-5-13(6-8-15)14-4-3-9-18-10-14/h5-8,11-12,14,18H,2-4,9-10H2,1H3,(H,19,20,21)/t14-/m1/s1
PubChem CID68325869
ChEMBLCHEMBL3702012
IUPHARN/A
BindingDB129472
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki21.2 nM, NoneBindingDB,ChEMBL

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