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Name | P2Y purinoceptor 6 |
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Species | Homo sapiens (Human) |
Gene | P2RY6 |
Synonym | pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 [ Show all ] |
Disease | N/A |
Length | 328 |
Amino acid sequence | MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR |
UniProt | Q15077 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15077 |
3D structure model | This predicted structure model is from GPCR-EXP Q15077. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4714 |
IUPHAR | 326 |
DrugBank | N/A |
Name | CHEMBL1765118 |
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Molecular formula | C18H21F2N2O15P3 |
IUPAC name | [[[[(2R,3S,4R,5R)-5-(2,4-dioxo-3-phenacylpyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]-difluoromethyl]phosphonic acid |
Molecular weight | 636.283 |
Hydrogen bond acceptor | 17 |
Hydrogen bond donor | 6 |
XlogP | -3.9 |
Synonyms | BDBM50341900 3-Phenacyl-5''-uridylic Acid(1,1-Difluoro-1-phosphonomethyl-1-phosphonyl)anhydride |
Inchi Key | CSVGAEIOFXFKIT-DTZQCDIJSA-N |
Inchi ID | InChI=1S/C18H21F2N2O15P3/c19-18(20,38(28,29)30)39(31,32)37-40(33,34)35-9-12-14(25)15(26)16(36-12)21-7-6-13(24)22(17(21)27)8-11(23)10-4-2-1-3-5-10/h1-7,12,14-16,25-26H,8-9H2,(H,31,32)(H,33,34)(H2,28,29,30)/t12-,14-,15-,16-/m1/s1 |
PubChem CID | 52952604 |
ChEMBL | CHEMBL1765118 |
IUPHAR | N/A |
BindingDB | 50341900 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 1460.0 nM | PMID21417463 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417