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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Homo sapiens (Human)
Gene	PTAFR
Synonym	PAFr PAF-R PAF receptor AGEPC receptor
Disease	Nerve injury Ocular allergy Pain Unspecified Psoriasis Septic shock Solid tumours Stroke Thrombocytopenia Thromboembolism Inflammatory disease Inflammatory bowel disease Conjunctivitis Cerebral infarction Cardiac arrhythmias Allergy Asthma Brain ischaemia [ Show all ]
Length	342
Amino acid sequence	MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
UniProt	P25105
Protein Data Bank	5zkq, 5zkp
GPCR-HGmod model	P25105
3D structure model	This structure is from PDB ID 5zkq.
BioLiP	BL0417415, BL0417417,BL0417419, BL0417416,BL0417418, BL0417414
Therapeutic Target Database	T87023
ChEMBL	CHEMBL250
IUPHAR	334
DrugBank	BE0005561

Ligand

Name	CHEMBL37952
Molecular formula	C20H23NO4
IUPAC name	3-[(E)-3-[5-(3,4-dimethoxyphenyl)oxolan-2-yl]oxyprop-1-enyl]pyridine
Molecular weight	341.407
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.1
Synonyms	3-{(E)-3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-yloxy]-propenyl}-pyridine BDBM50282014
Inchi Key	CSFAXQWSXQRRAJ-GQCTYLIASA-N
Inchi ID	InChI=1S/C20H23NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3-8,11,13-14,17,20H,9-10,12H2,1-2H3/b6-4+
PubChem CID	44283998
ChEMBL	CHEMBL37952
IUPHAR	N/A
BindingDB	50282014
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	300.0 nM	, Bioorg. Med. Chem. Lett., (1993) 3:8:1493	BindingDB,ChEMBL

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