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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL337588
Molecular formula	C35H32Cl2N4O6S
IUPAC name	ethyl 4-[3-butyl-4-[[4-[2-[(2-chlorobenzoyl)sulfamoyl]phenyl]phenyl]methyl]-5-oxo-1,2,4-triazol-1-yl]-3-chlorobenzoate
Molecular weight	707.623
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	7.5
Synonyms	3-Chloro-4-[[3-butyl-5-oxo-4,5-dihydro-4-[[2'-[[(2-chlorobenzoyl)amino]sulfonyl]-1,1'-biphenyl-4-yl]methyl]-1H-1,2,4-triazol]-1-yl]benzoic acid ethyl ester BDBM50035436 4-{3-Butyl-4-[2''-(2-chloro-benzoylsulfamoyl)-biphenyl-4-ylmethyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-3-chloro-benzoic acid ethyl ester
Inchi Key	CRLZFHPTTUYING-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H32Cl2N4O6S/c1-3-5-14-32-38-41(30-20-19-25(21-29(30)37)34(43)47-4-2)35(44)40(32)22-23-15-17-24(18-16-23)26-10-7-9-13-31(26)48(45,46)39-33(42)27-11-6-8-12-28(27)36/h6-13,15-21H,3-5,14,22H2,1-2H3,(H,39,42)
PubChem CID	9987311
ChEMBL	CHEMBL337588
IUPHAR	N/A
BindingDB	50035436
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	201.0 nM	PMID7799397	BindingDB,ChEMBL

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