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GPCR

NameG-protein coupled receptor family C group 6 member A
SpeciesMus musculus (Mouse)
GeneGprc6a
SynonymG protein-coupled receptor
G protein-coupled receptor, class C, group 6, member A
G protein-coupled receptor, family C, group 6, member A
GPCR6A
GPRC6 receptor
DiseaseN/A for non-human GPCRs
Length928
Amino acid sequenceMALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
UniProtQ8K4Z6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3347255
IUPHAR55
DrugBankN/A

Ligand

NameCHEMBL3633654
Molecular formulaC24H27N3O4
IUPAC name1-(5-methoxy-2-phenyl-1H-indol-3-yl)-2-[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]ethanone
Molecular weight421.497
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.6
SynonymsBDBM50133680
Inchi KeyLYIHJKGXTOKLHM-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H27N3O4/c1-26(16-22(29)27-10-12-31-13-11-27)15-21(28)23-19-14-18(30-2)8-9-20(19)25-24(23)17-6-4-3-5-7-17/h3-9,14,25H,10-13,15-16H2,1-2H3
PubChem CID122195445
ChEMBLCHEMBL3633654
IUPHARN/A
BindingDB50133680
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5066069.0 nMPMID26516782BindingDB
IC5066069.3 nMPMID26516782ChEMBL
IC5066100.0 nMPMID26516782BindingDB,ChEMBL
Inhibition33.0 %PMID26516782ChEMBL

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