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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3641740
Molecular formula	C17H19FN4O
IUPAC name	4-cyclopropyl-5-fluoro-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight	314.364
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.8
Synonyms	SCHEMBL12610086 US8802673, 190 BDBM129548
Inchi Key	CRCJWDIBTPRFQN-HNNXBMFYSA-N
Inchi ID	InChI=1S/C17H19FN4O/c18-14-9-20-17(22-16(14)12-1-2-12)21-13-5-3-11(4-6-13)15-10-19-7-8-23-15/h3-6,9,12,15,19H,1-2,7-8,10H2,(H,20,21,22)/t15-/m0/s1
PubChem CID	68325767
ChEMBL	CHEMBL3641740
IUPHAR	N/A
BindingDB	129548
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3.1 nM	, None	BindingDB,ChEMBL

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