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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	SMR000060793
Molecular formula	C23H31N3O6S
IUPAC name	2-[4-[2-hydroxy-3-(4-morpholin-4-ylsulfonylphenoxy)propyl]piperazin-1-yl]phenol
Molecular weight	477.576
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	1.3
Synonyms	2-[4-[2-hydroxy-3-(4-morpholin-4-ylsulfonylphenoxy)propyl]piperazin-1-yl]phenol MCULE-4697345090 AC1MHC2Q MolPort-004-247-305 CHEMBL1350084 716375-94-9 MLS000054455 AKOS034456039 2-(4-{2-hydroxy-3-[4-(morpholine-4-sulfonyl)phenoxy]propyl}piperazin-1-yl)phenol HMS2493G22 AB00425576-09 MLS000879856 Z56798524 [ Show all ]
Inchi Key	FNAQITQLNSNPNB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H31N3O6S/c27-19(17-24-9-11-25(12-10-24)22-3-1-2-4-23(22)28)18-32-20-5-7-21(8-6-20)33(29,30)26-13-15-31-16-14-26/h1-8,19,27-28H,9-18H2
PubChem CID	2999575
ChEMBL	CHEMBL1350084
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1258.9 nM	PubChem BioAssay data set	ChEMBL

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