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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	CHEMBL3289643
Molecular formula	C21H23ClN2O
IUPAC name	2-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-2,3-dihydroinden-1-one
Molecular weight	354.878
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.3
Synonyms	BDBM50017967
Inchi Key	CPFAMVVFLCOFSK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClN2O/c22-18-5-7-19(8-6-18)24-13-11-23(12-14-24)10-9-17-15-16-3-1-2-4-20(16)21(17)25/h1-8,17H,9-15H2
PubChem CID	90644059
ChEMBL	CHEMBL3289643
IUPHAR	N/A
BindingDB	50017967
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4534.0 nM	PMID24800940	BindingDB,ChEMBL
Ki	4570.88 nM	PMID24800940	ChEMBL

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