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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3641694
Molecular formula	C14H18N4O
IUPAC name	1-methyl-N-(4-morpholin-2-ylphenyl)pyrazol-3-amine
Molecular weight	258.325
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.1
Synonyms	BDBM129498 SCHEMBL12610056 US8802673, 140
Inchi Key	CPAWBSUVPJCERW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H18N4O/c1-18-8-6-14(17-18)16-12-4-2-11(3-5-12)13-10-15-7-9-19-13/h2-6,8,13,15H,7,9-10H2,1H3,(H,16,17)
PubChem CID	68325752
ChEMBL	CHEMBL3641694
IUPHAR	N/A
BindingDB	129498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	38.6 nM	, None	BindingDB,ChEMBL

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