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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	Piribedil mesylate
Molecular formula	C17H22N4O5S
IUPAC name	2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine;methanesulfonic acid
Molecular weight	394.446
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	None
Synonyms	Piribedil monomethanesulfonate 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; methanesulfonic acid AKOS015918393 HMS3373M21 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate (9CI) 3605-01-4 (Parent) CHEMBL1468572 MLS000028838 Piribedil methanesulfonate SMR000058709 1U37NGM6KK AC1L5518 ET 495 methanesulfonate Piribedil monomethylsulfonate 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine; methanesulfonic acid C16H18N4O2.CH4O3S I14-7668 Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-, methanesulfonate 52293-23-9 DTXSID30200314 Opera_ID_1848 Piribedil methylsulfonate UNII-1U37NGM6KK 2-(4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl)pyrimidinium methanesulphonate ACM52293239 HMS2230N20 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl]pyrimidinium methanesulfonate LS-135518 SCHEMBL1652330 1-(3,4-METHYLENEDIOXYBENZYL)-4-(2-PYRIMIDYL)-PIPERAZINE MONO(METHANESULFONATE) SALT A823101 EINECS 257-818-8 [ Show all ]
Inchi Key	DEZKFCIOSKCCHK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N4O2.CH4O3S/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;1-5(2,3)4/h1-5,10H,6-9,11-12H2;1H3,(H,2,3,4)
PubChem CID	198284
ChEMBL	CHEMBL1468572
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	141.3 nM	PubChem BioAssay data set	ChEMBL

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