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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	MLS000735390
Molecular formula	C19H25ClN2O2
IUPAC name	1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone
Molecular weight	348.871
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.8
Synonyms	CHEMBL1562790 1-[4-[3-(3-chlorobenzoyl)piperidino]piperidino]ethanone BDBM90434 (1'-acetyl-1,4'-bipiperidin-3-yl)(3-chlorophenyl)methanone cid_16192411 1-[4-[3-(3-chlorophenyl)carbonylpiperidin-1-yl]piperidin-1-yl]ethanone SMR000318236 1-[4-[3-(3-chlorobenzoyl)piperidin-1-yl]piperidin-1-yl]ethanone HMS2632M07 1-[4-[3-[(3-chlorophenyl)-oxomethyl]-1-piperidinyl]-1-piperidinyl]ethanone [ Show all ]
Inchi Key	DABYACYEBJAZDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25ClN2O2/c1-14(23)21-10-7-18(8-11-21)22-9-3-5-16(13-22)19(24)15-4-2-6-17(20)12-15/h2,4,6,12,16,18H,3,5,7-11,13H2,1H3
PubChem CID	16192411
ChEMBL	CHEMBL1562790
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	56234.1 nM	PubChem BioAssay data set	ChEMBL

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