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GPCR

NameG-protein coupled receptor family C group 6 member A
SpeciesMus musculus (Mouse)
GeneGprc6a
SynonymG protein-coupled receptor
G protein-coupled receptor, class C, group 6, member A
G protein-coupled receptor, family C, group 6, member A
GPCR6A
GPRC6 receptor
DiseaseN/A for non-human GPCRs
Length928
Amino acid sequenceMALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
UniProtQ8K4Z6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3347255
IUPHAR55
DrugBankN/A

Ligand

NameCHEMBL3633653
Molecular formulaC23H27N3O2
IUPAC name2-[methyl-[2-(2-phenyl-1H-indol-3-yl)ethyl]amino]-1-morpholin-4-ylethanone
Molecular weight377.488
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.2
SynonymsBDBM50133678
Inchi KeyBMRHNVJLVLCNEE-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27N3O2/c1-25(17-22(27)26-13-15-28-16-14-26)12-11-20-19-9-5-6-10-21(19)24-23(20)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
PubChem CID122195444
ChEMBLCHEMBL3633653
IUPHARN/A
BindingDB50133678
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50131826.0 nMPMID26516782ChEMBL
IC50131826.0 nMPMID26516782BindingDB
IC50132000.0 nMPMID26516782BindingDB,ChEMBL
Inhibition17.0 %PMID26516782ChEMBL

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