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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3616674
Molecular formula	C32H23F6N3O4
IUPAC name	3-[[4-[1-[6-[4-(trifluoromethoxy)phenyl]-3-(2,3,5-trifluorophenyl)indazol-1-yl]ethyl]benzoyl]amino]propanoic acid
Molecular weight	627.543
Hydrogen bond acceptor	11
Hydrogen bond donor	2
XlogP	7.1
Synonyms	BDBM50120326
Inchi Key	BIXZGCLRWDRIEC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H23F6N3O4/c1-17(18-2-4-20(5-3-18)31(44)39-13-12-28(42)43)41-27-14-21(19-6-9-23(10-7-19)45-32(36,37)38)8-11-24(27)30(40-41)25-15-22(33)16-26(34)29(25)35/h2-11,14-17H,12-13H2,1H3,(H,39,44)(H,42,43)
PubChem CID	122189695
ChEMBL	CHEMBL3616674
IUPHAR	N/A
BindingDB	50120326
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.0 nM	PMID26303893	ChEMBL
IC50	7.0 nM	PMID26303893	BindingDB
IC50	52.0 nM	PMID26303893	BindingDB,ChEMBL

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