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Name | D(3) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD3 |
Synonym | dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor |
Disease | Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders [ Show all ] |
Length | 400 |
Amino acid sequence | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC |
UniProt | P35462 |
Protein Data Bank | 3pbl |
GPCR-HGmod model | P35462 |
3D structure model | This structure is from PDB ID 3pbl. |
BioLiP | BL0191566, BL0191567 |
Therapeutic Target Database | T02551 |
ChEMBL | CHEMBL234 |
IUPHAR | 216 |
DrugBank | BE0000581 |
Name | CHEMBL3588983 |
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Molecular formula | C29H33N5O |
IUPAC name | 1-(2-methoxyphenyl)-4-[4-[4-(4-phenylphenyl)triazol-1-yl]butyl]piperazine |
Molecular weight | 467.617 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | BDBM50097846 |
Inchi Key | ATOMZLGTVBAGNB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H33N5O/c1-35-29-12-6-5-11-28(29)33-21-19-32(20-22-33)17-7-8-18-34-23-27(30-31-34)26-15-13-25(14-16-26)24-9-3-2-4-10-24/h2-6,9-16,23H,7-8,17-22H2,1H3 |
PubChem CID | 122180612 |
ChEMBL | CHEMBL3588983 |
IUPHAR | N/A |
BindingDB | 50097846 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 5.88 nM | PMID25650314 | ChEMBL |
Ki | 5.9 nM | PMID25650314 | BindingDB |
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