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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Sphingosine 1-phosphate receptor 2
Species	Rattus norvegicus (Rat)
Gene	S1pr2
Synonym	S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 GPCR18 Gpcr13 G-protein coupled receptor H218 G protein-coupled receptor 13 Endothelial differentiation G-protein coupled receptor 5 endothelial differentiation G protein-coupled receptor 5 edg5 AGR16 Sphingosine 1-phosphate receptor Edg-5 [ Show all ]
Disease	N/A for non-human GPCRs
Length	352
Amino acid sequence	MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
UniProt	P47752
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3616360
IUPHAR	276
DrugBank	N/A

Ligand

Name	CHEMBL3703199
Molecular formula	C33H40FN3O5
IUPAC name	4-(2-ethylbutyl)-N-[3-[4-(ethylcarbamoyl)phenoxy]-5-(4-fluorophenoxy)phenyl]-4-hydroxypiperidine-1-carboxamide
Molecular weight	577.697
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	6.4
Synonyms	US8975409, Example 15(1) BDBM149707 SCHEMBL14839336
Inchi Key	OHOPIJDKZBJLAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H40FN3O5/c1-4-23(5-2)22-33(40)15-17-37(18-16-33)32(39)36-26-19-29(21-30(20-26)42-28-13-9-25(34)10-14-28)41-27-11-7-24(8-12-27)31(38)35-6-3/h7-14,19-21,23,40H,4-6,15-18,22H2,1-3H3,(H,35,38)(H,36,39)
PubChem CID	89484793
ChEMBL	CHEMBL3703199
IUPHAR	N/A
BindingDB	149707
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9.6 nM	, None	BindingDB,ChEMBL

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