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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	Linifanib
Molecular formula	C21H18FN5O
IUPAC name	1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
Molecular weight	375.407
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	3.9
Synonyms	FT-0670795 JSPY-st000257 Linifanib [USAN:INN] NCGC00250403-01 RS0095 SW218116-2 ABT-869 AKOS015919098 BC640336 cid_11485656 HMS3244D10 KS-00000I9Z MolPort-009-679-408 PubChem22400 s1003 796967-16-3 Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)- ABT869 AL39324 BCPP000446 CTK8F0042 HY-50751 Linifanib (USAN/INN) N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea RG-3635 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea SCHEMBL93804 ABP000856 ZINC6718813 AJ-56734 AOB87120 CHEBI:91435 DTXSID40229834 GTPL5657 KB-08836 linifanibum PB34634 RT-011155 3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea SYN1002 ABT-869(Linifanib)/AL-39324,RG3635/ AL 39324 BCP01726 CO93X137CW HMS3244D14 MPVGZUGXCQEXTM-UHFFFAOYSA-N Q-2136 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea S1003_Selleck AB0008062 VZ31170 ABT869, Linifanib, AL-39324, RG3635 Aminoindazole, 3 BDBM21079 D09635 EX-A014 J-503186 Linifanib - ABT-869 N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea RG3635 1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea SMR004701346 ABT 869 AK-40846 AS-16177 CHEMBL223360 HMS3244D06 Kinome_532 MLS006010276 PC402063 S06-0034 4CA-0745 UNII-CO93X137CW ABT-869,Linifanib AL-39324 BCP9000220 CS-0115 HMS3654E03 Linifanib (ABT-869) N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea QCR-97 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea SC-87820 AB1008464 X7465 AC-24279 AN-503 BRD-K99749624-001-01-3 D0M9QZ [ Show all ]
Inchi Key	MPVGZUGXCQEXTM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
PubChem CID	11485656
ChEMBL	N/A
IUPHAR	N/A
BindingDB	21079
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	3900000.0 nM	N/A	BindingDB

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