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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Mus musculus (Mouse)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	P58406
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3263
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL336499
Molecular formula	C14H23N3O2
IUPAC name	3-(1H-imidazol-5-yl)propyl N-(2,2,3,3-tetramethylcyclopropyl)carbamate
Molecular weight	265.357
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.7
Synonyms	BDBM50409577
Inchi Key	CMPGZDKNYUIAPE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H23N3O2/c1-13(2)11(14(13,3)4)17-12(18)19-7-5-6-10-8-15-9-16-10/h8-9,11H,5-7H2,1-4H3,(H,15,16)(H,17,18)
PubChem CID	10869191
ChEMBL	CHEMBL336499
IUPHAR	N/A
BindingDB	50409577
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<10.0 mg.kg-1	PMID12190321	ChEMBL

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