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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	LY 213024
Molecular formula	C27H34O6
IUPAC name	3-[3-(2-carboxyethyl)-4-decoxybenzoyl]benzoic acid
Molecular weight	454.563
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	7.0
Synonyms	5-(3-carboxybenzoyl)-2-(decyloxy)benzenepropanoic acid Benzenepropanoic acid,5-(3-carboxybenzoyl)-2-(decyloxy)- SCHEMBL7959129 AC1Q5U3H CMMZAOHHIRUNGK-UHFFFAOYSA-N 117423-95-7 BDBM50045096 3-[3-(2-carboxyethyl)-4-(decyloxy)benzoyl]benzoic acid ACMC-20ckre CTK4B0283 3'-Carboxy-4-decyloxybenzophenone-3-propanoic acid Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-(decyloxy)- LY-213024 3-[3-(2-carboxyethyl)-4-decoxybenzoyl]benzoic acid AC1L4ZMF CHEMBL48068 AKOS030585056 DTXSID00151783 3-[3-(2-Carboxy-ethyl)-4-decyloxy-benzoyl]-benzoic acid [ Show all ]
Inchi Key	CMMZAOHHIRUNGK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H34O6/c1-2-3-4-5-6-7-8-9-17-33-24-15-13-22(18-20(24)14-16-25(28)29)26(30)21-11-10-12-23(19-21)27(31)32/h10-13,15,18-19H,2-9,14,16-17H2,1H3,(H,28,29)(H,31,32)
PubChem CID	195214
ChEMBL	CHEMBL48068
IUPHAR	N/A
BindingDB	50045096
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	210.0 nM	PMID8389876	BindingDB,ChEMBL
Inhibition	7.0 %	PMID2170648	ChEMBL
Inhibition	60.0 %	PMID2170647	ChEMBL
Inhibition	95.0 %	PMID2170647	ChEMBL
Relative potency	10.0 -	PMID8389876	ChEMBL

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