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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 39
Species	Homo sapiens (Human)
Gene	GPR39
Synonym	GPR39
Disease	Diabetes
Length	453
Amino acid sequence	MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
UniProt	O43194
Protein Data Bank	N/A
GPCR-HGmod model	O43194
3D structure model	This predicted structure model is from GPCR-EXP O43194.
BioLiP	N/A
Therapeutic Target Database	T88531
ChEMBL	CHEMBL3091266
IUPHAR	105
DrugBank	N/A

Ligand

Name	CHEMBL3342364
Molecular formula	C15H19N5
IUPAC name	4-N-(cyclopropylmethyl)-2-N,2-N-dimethyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Molecular weight	269.352
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.3
Synonyms	BDBM50030768
Inchi Key	QTJORYMKMUGJAQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H19N5/c1-20(2)15-18-13(12-5-3-4-8-16-12)9-14(19-15)17-10-11-6-7-11/h3-5,8-9,11H,6-7,10H2,1-2H3,(H,17,18,19)
PubChem CID	118716407
ChEMBL	CHEMBL3342364
IUPHAR	N/A
BindingDB	50030768
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<25000.0 nM	PMID25313322	BindingDB,ChEMBL

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