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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL67602
Molecular formulaC17H21F3N4O
IUPAC name4-[2-(1H-imidazol-5-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]pentanamide
Molecular weight354.377
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP2.4
SynonymsN/A
Inchi KeyPSYDAFYPUVMSLN-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H21F3N4O/c1-12(22-9-8-15-10-21-11-23-15)2-7-16(25)24-14-5-3-13(4-6-14)17(18,19)20/h3-6,10-12,22H,2,7-9H2,1H3,(H,21,23)(H,24,25)
PubChem CID13974541
ChEMBLCHEMBL67602
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency0.0 -PMID2959777ChEMBL

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