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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL115382
Molecular formulaC21H26ClN5O
IUPAC name2-[3-[4-(3-chlorophenyl)-3-methylpiperazin-1-yl]-2-methylpropyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
Molecular weight399.923
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.7
Synonyms2-[2-[4-(3-Chlorophenyl)-3-methylpiperazinomethyl]propyl]-1,2,4-triazolo[4,3-a]pyridine-3(2H)-one
Inchi KeyLOEADZDEGAOQMK-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26ClN5O/c1-16(14-27-21(28)26-9-4-3-8-20(26)23-27)13-24-10-11-25(17(2)15-24)19-7-5-6-18(22)12-19/h3-9,12,16-17H,10-11,13-15H2,1-2H3
PubChem CID10787137
ChEMBLCHEMBL115382
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition0.0 %PMID9986703ChEMBL

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