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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3354774
Molecular formula	C26H24F3N3O2
IUPAC name	ethyl (2R)-2-methyl-2-[6-methyl-3-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]-3-phenylpropanoate
Molecular weight	467.492
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.7
Synonyms	BDBM50036636 SCHEMBL1245002
Inchi Key	KWIOPQKUZLWYEN-RUZDIDTESA-N
Inchi ID	InChI=1S/C26H24F3N3O2/c1-4-34-24(33)25(3,14-18-8-6-5-7-9-18)22-17(2)15-30-23-21(16-31-32(22)23)19-10-12-20(13-11-19)26(27,28)29/h5-13,15-16H,4,14H2,1-3H3/t25-/m1/s1
PubChem CID	49855246
ChEMBL	CHEMBL3354774
IUPHAR	N/A
BindingDB	50036636
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	11.0 nM	PMID25455488	BindingDB,ChEMBL
Efficacy	62.0 %	PMID25455488	ChEMBL

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