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Name | Extracellular calcium-sensing receptor |
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Species | Homo sapiens (Human) |
Gene | CASR |
Synonym | hCasR {ECO:0000303|PubMed:27386547} GPRC2A extracellular calcium-sensing receptor Parathyroid cell calcium-sensing receptor 1 {ECO:0000303|PubMed:8698326} PCaR1 {ECO:0000303|PubMed:8698326} [ Show all ] |
Disease | Osteoporosis Cerebrovascular ischaemia Cardiovascular disease; Kidney disease Secondary hyperparathyroidism Myelodysplastic syndrome [ Show all ] |
Length | 1078 |
Amino acid sequence | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS |
UniProt | P41180 |
Protein Data Bank | 5k5t, 5k5s, 5fbk, 5fbh |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5k5t. |
BioLiP | BL0353424,BL0353430, BL0353434, BL0353425,BL0353426,BL0353427,, BL0349612,BL0349615, BL0349611,BL0349614, BL0349610,BL0349613, BL0349606,BL0349609, BL0349605,BL0349608, BL0349604,BL0349607 |
Therapeutic Target Database | T92076 |
ChEMBL | CHEMBL1878 |
IUPHAR | 54 |
DrugBank | BE0000509 |
Name | CHEMBL523682 |
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Molecular formula | C30H32N4O6 |
IUPAC name | 2-[(4-methoxyphenyl)methylamino]-N-(2-phenoxyethyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine-5-carboxamide |
Molecular weight | 544.608 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 4.5 |
Synonyms | BDBM27986 trisubstituted pyrimidine analogue, 6g 2-{[(4-methoxyphenyl)methyl]amino}-N-(2-phenoxyethyl)-4-(3,4,5-trimethoxyphenyl)pyrimidine-5-carboxamide |
Inchi Key | CLINIMPOUCLOTA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H32N4O6/c1-36-22-12-10-20(11-13-22)18-32-30-33-19-24(29(35)31-14-15-40-23-8-6-5-7-9-23)27(34-30)21-16-25(37-2)28(39-4)26(17-21)38-3/h5-13,16-17,19H,14-15,18H2,1-4H3,(H,31,35)(H,32,33,34) |
PubChem CID | 25218704 |
ChEMBL | CHEMBL523682 |
IUPHAR | N/A |
BindingDB | 27986 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
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IC50 | 3100.0 nM | PMID19143533 | BindingDB,ChEMBL |
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