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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasopressin V1a receptor
Species	Mus musculus (Mouse)
Gene	Avpr1a
Synonym	Antidiuretic hormone receptor 1a AVPR AVPR V1a AVPR1 V1A receptor V1aR Vascular/hepatic-type arginine vasopressin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	423
Amino acid sequence	MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFVLSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIPVST
UniProt	Q62463
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3414410
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3416872
Molecular formula	C20H18ClN3O2
IUPAC name	(6-chloro-1H-indol-3-yl)-spiro[7H-furo[3,4-b]pyridine-5,4'-piperidine]-1'-ylmethanone
Molecular weight	367.833
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.4
Synonyms	BDBM50077249 SCHEMBL2512006
Inchi Key	IPIIGNYKOUWWDJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18ClN3O2/c21-13-3-4-14-15(11-23-17(14)10-13)19(25)24-8-5-20(6-9-24)16-2-1-7-22-18(16)12-26-20/h1-4,7,10-11,23H,5-6,8-9,12H2
PubChem CID	25001616
ChEMBL	CHEMBL3416872
IUPHAR	N/A
BindingDB	50077249
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4816.0 nM	PMID25654260	BindingDB,ChEMBL

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