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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3357998
Molecular formulaC21H23F3N6O4S
IUPAC name2-[(3R)-3-methyl-4-[5-[[4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]piperazin-1-yl]-5-(trifluoromethyl)-1,3,4-oxadiazole
Molecular weight512.508
Hydrogen bond acceptor13
Hydrogen bond donor0
XlogP2.4
SynonymsBDBM50103559
Inchi KeyIDFYVOMBWZBNGK-CQSZACIVSA-N
Inchi IDInChI=1S/C21H23F3N6O4S/c1-14-11-29(20-28-27-18(34-20)21(22,23)24)7-8-30(14)19-25-9-17(10-26-19)33-12-15-3-5-16(6-4-15)13-35(2,31)32/h3-6,9-10,14H,7-8,11-13H2,1-2H3/t14-/m1/s1
PubChem CID118722574
ChEMBLCHEMBL3357998
IUPHARN/A
BindingDB50103559
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50319.0 nMPMID25286150BindingDB,ChEMBL
Intrinsic activity95.0 %PMID25286150ChEMBL

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