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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	HALOPERIDOL DECANOATE
Molecular formula	C31H41ClFNO3
IUPAC name	[4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate
Molecular weight	530.121
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	7.9
Synonyms	DECANOIC ACID 4-(4-CHLOROPHENYL)-1-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-4-PIPERIDINYL ESTER Haldol decanoas Haloperidol decanoate [USAN:USP:BAN:JAN] R 13,672 ZINC8214574 API0024496 Depot haloperidol Halomonth (TN) KD 16 R-13,672 74050-97-8 CHEBI:31664 CTK5D9276 FT-0669103 Haloperidol Decanoate HCl LS-59345 UNII-AC20PJ4101 AC20PJ4101 Decanoic acid, 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl ester Haldol decanoate Haloperidol depot R 13672 [4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate 4-(4-Chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidyl decanoate BDBM50053408 DTXSID50224951 KD-136 R-13672 77129-05-6 D01898 Haldol Dec Haloperidol decanoate [USAN:BAN:JAN] MolPort-006-137-967 W0040 AKOS025392169 Decanoic acid, ester with 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone Halomonth KD 136 R 13762 C31H41ClFNO3 CHEMBL1200986 EINECS 277-679-7 Haloperidol decanoate (JAN/USAN) KS-1419 SCHEMBL120575 AC1L1DVL [ Show all ]
Inchi Key	GUTXTARXLVFHDK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3
PubChem CID	52919
ChEMBL	CHEMBL1200986
IUPHAR	N/A
BindingDB	50053408
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.8 nM	PMID25047579	BindingDB,ChEMBL

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