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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL274767
Molecular formula	C22H27N3
IUPAC name	2-[2-(5,5-diphenylpentyl)-1H-imidazol-5-yl]ethanamine
Molecular weight	333.479
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50409187 2-(5,5-Diphenylpentyl)-1H-imidazole-4-ethanamine
Inchi Key	CKMBGNSZMPWQNH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N3/c23-16-15-20-17-24-22(25-20)14-8-7-13-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-6,9-12,17,21H,7-8,13-16,23H2,(H,24,25)
PubChem CID	10246247
ChEMBL	CHEMBL274767
IUPHAR	N/A
BindingDB	50409187
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Concentration	5.0 nM	PMID10737740	ChEMBL
Emax	0.0 -	PMID10737740	ChEMBL
Kd	831.76 nM	PMID10737740	BindingDB,ChEMBL
Kd	1000.0 nM	PMID10737740	BindingDB,ChEMBL

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