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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	CHEMBL3361316
Molecular formula	C24H19ClN2O3
IUPAC name	9b-(4-chlorophenyl)-1-(3-methoxybenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one
Molecular weight	418.877
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.1
Synonyms	AKOS005085786 VU0477669-1 9b-(4-chlorophenyl)-1-(3-methoxybenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one MolPort-002-862-669 2M-546S BDBM50042348 9b-(4-chlorophenyl)-1-(3-methoxybenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one KS-000034CJ AC1MX5CU Oprea1_248959 477886-54-7 9b-(4-chlorophenyl)-1-(3-methoxybenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one MCULE-1693106672 [ Show all ]
Inchi Key	AXWICKMMFGIVMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H19ClN2O3/c1-30-19-6-4-5-16(15-19)22(28)26-13-14-27-23(29)20-7-2-3-8-21(20)24(26,27)17-9-11-18(25)12-10-17/h2-12,15H,13-14H2,1H3
PubChem CID	3810205
ChEMBL	CHEMBL3361316
IUPHAR	N/A
BindingDB	50042348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6600.0 nM	PMID25542588	BindingDB,ChEMBL
IC50	6606.93 nM	PMID25542588	ChEMBL
IC50	6607.0 nM	PMID25542588	BindingDB

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