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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392168
Molecular formula	C17H10BrNO5
IUPAC name	8-benzamido-6-bromo-4-oxochromene-2-carboxylic acid
Molecular weight	388.173
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.8
Synonyms	BDBM50436021
Inchi Key	ZZDAUAMGTZSVHO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H10BrNO5/c18-10-6-11-13(20)8-14(17(22)23)24-15(11)12(7-10)19-16(21)9-4-2-1-3-5-9/h1-8H,(H,19,21)(H,22,23)
PubChem CID	71733745
ChEMBL	CHEMBL2392168
IUPHAR	N/A
BindingDB	50436021
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	303.0 nM	PMID23713606, PMID23888932	BindingDB,ChEMBL
Emax	110.0 %	PMID23713606	ChEMBL
Ki	81.6 nM	PMID23888932	ChEMBL
Ki	82.0 nM	PMID23888932	BindingDB

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