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GPCR

NameD(2) dopamine receptor
SpeciesCanis lupus familiaris (Dog)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLESQNWSRPFNGSEGKPGKPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTERSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTADSPAKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCECNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtQ9GJU1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2703
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL39689
Molecular formulaC17H28ClN3O4
IUPAC name4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(2-methoxyethoxymethoxy)benzamide
Molecular weight373.878
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.4
SynonymsZVPMWLYIHMIYJK-UHFFFAOYSA-N
4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-methoxy-ethoxymethoxy)-benzamide
BDBM50023823
SCHEMBL9777186
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(2-methoxyethoxy)methyloxy]benzamide
Inchi KeyZVPMWLYIHMIYJK-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H28ClN3O4/c1-4-21(5-2)7-6-20-17(22)13-10-14(18)15(19)11-16(13)25-12-24-9-8-23-3/h10-11H,4-9,12,19H2,1-3H3,(H,20,22)
PubChem CID14116940
ChEMBLCHEMBL39689
IUPHARN/A
BindingDB50023823
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<3.0 mg.kg-1PMID3397992ChEMBL

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