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Name | Prostaglandin E2 receptor EP4 subtype |
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Species | Rattus norvegicus (Rat) |
Gene | Ptger4 |
Synonym | EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor |
Disease | N/A for non-human GPCRs |
Length | 488 |
Amino acid sequence | MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI |
UniProt | P43114 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4086 |
IUPHAR | 343 |
DrugBank | N/A |
Name | CHEMBL550015 |
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Molecular formula | C16H33NO5S |
IUPAC name | 7-[(4-hydroxy-6-methylheptyl)-methylsulfonylamino]heptanoic acid |
Molecular weight | 351.502 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.4 |
Synonyms | BDBM50293499 7-(N-(4-hydroxy-6-methylheptyl)methylsulfonamido)heptanoic acid |
Inchi Key | ZVOQGQCKCWWWMA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H33NO5S/c1-14(2)13-15(18)9-8-12-17(23(3,21)22)11-7-5-4-6-10-16(19)20/h14-15,18H,4-13H2,1-3H3,(H,19,20) |
PubChem CID | 45270403 |
ChEMBL | CHEMBL550015 |
IUPHAR | N/A |
BindingDB | 50293499 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <3200.0 nM | PMID19250823 | BindingDB,ChEMBL |
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