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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	339071-18-0
Molecular formula	C11H14ClN3O2
IUPAC name	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Molecular weight	255.702
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	DS-16349 N-(3-Chloro-4-morpholinophenyl)-N-hydroxyformimidamide AKOS022180267 Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy- ZINC6746071 (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide CTK1B8099 N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine AJ-56824 DTXSID00431234 SCHEMBL3983851 BDBM86694 MolPort-035-681-438 D09LKR N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide AK-59782 HY-15603 TS-011 CS-0007825 MolPort-044-723-707 [ Show all ]
Inchi Key	ZTXADXBIGLLOFX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
PubChem CID	9816527
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86694
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15831442	BindingDB

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