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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Rattus norvegicus (Rat)
Gene	Crhr1
Synonym	CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor CRF-RA CRF-R1alpha CRF-R1 CRF-R-1 CRF-R CRF 1 receptor Corticotropin-releasing hormone receptor 1 CRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P35353
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4649
IUPHAR	212
DrugBank	N/A

Ligand

Name	339071-18-0
Molecular formula	C11H14ClN3O2
IUPAC name	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Molecular weight	255.702
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy- ZINC6746071 AKOS022180267 CTK1B8099 N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide DTXSID00431234 SCHEMBL3983851 AJ-56824 BDBM86694 MolPort-035-681-438 D09LKR N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide HY-15603 TS-011 AK-59782 CS-0007825 MolPort-044-723-707 DS-16349 N-(3-Chloro-4-morpholinophenyl)-N-hydroxyformimidamide [ Show all ]
Inchi Key	ZTXADXBIGLLOFX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
PubChem CID	9816527
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86694
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15831442	BindingDB

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