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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Cavia porcellus (Guinea pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	376
Amino acid sequence	MSPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAGAMIAAVWVISICISIPPLFWRQAQAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRILNPPSLSGKRFTTAHLITGSAGSSLCSLNPSLHEGHMHPGSPLFFNHVRIKLADSVLERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS
UniProt	Q60484
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2304407
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Serotonin-O-carboxymethyl-gly-tyr
Molecular formula	C23H27N5O5
IUPAC name	(2S)-2-[[2-[[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanamide
Molecular weight	453.499
Hydrogen bond acceptor	6
Hydrogen bond donor	6
XlogP	0.6
Synonyms	AC1L2ZKP CHEMBL159174 133790-08-6 S-CM-Gtnh2 BDBM50286672 Serotonin-O-carboxymethyl-glycyl-tyrosinamide (2S)-2-[[2-[[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanamide DTXSID20158370 Serotonin-5-O-carboxymethyl-glycyl-tyrosinamide (S)-2-(2-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionamide L-Tyrosinamide, N-(((3-(2-aminoethyl)-1H-indol-5-yl)oxy)acetyl)glycyl- [ Show all ]
Inchi Key	ZRVNSPYTGPNZTB-FQEVSTJZSA-N
Inchi ID	InChI=1S/C23H27N5O5/c24-8-7-15-11-26-19-6-5-17(10-18(15)19)33-13-22(31)27-12-21(30)28-20(23(25)32)9-14-1-3-16(29)4-2-14/h1-6,10-11,20,26,29H,7-9,12-13,24H2,(H2,25,32)(H,27,31)(H,28,30)/t20-/m0/s1
PubChem CID	131670
ChEMBL	CHEMBL159174
IUPHAR	N/A
BindingDB	50286672
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor.

Experimental Data

Parameter	Value	Reference	Database source
IC50	60.0 nM	, Bioorg. Med. Chem. Lett., (1995) 5:7:663	BindingDB,ChEMBL

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