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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 5B
Species	Rattus norvegicus (Rat)
Gene	Htr5b
Synonym	MR22 HTR5B GPR134 G protein-coupled receptor 134 5-HT-5B 5Ht5b 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene 5-ht5b receptor 5-HT5B Serotonin receptor 5B [ Show all ]
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
UniProt	P35365
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2619
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Serotonin-O-carboxymethyl-gly-tyr
Molecular formula	C23H27N5O5
IUPAC name	(2S)-2-[[2-[[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanamide
Molecular weight	453.499
Hydrogen bond acceptor	6
Hydrogen bond donor	6
XlogP	0.6
Synonyms	AC1L2ZKP CHEMBL159174 133790-08-6 S-CM-Gtnh2 BDBM50286672 Serotonin-O-carboxymethyl-glycyl-tyrosinamide (2S)-2-[[2-[[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanamide DTXSID20158370 Serotonin-5-O-carboxymethyl-glycyl-tyrosinamide (S)-2-(2-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionamide L-Tyrosinamide, N-(((3-(2-aminoethyl)-1H-indol-5-yl)oxy)acetyl)glycyl- [ Show all ]
Inchi Key	ZRVNSPYTGPNZTB-FQEVSTJZSA-N
Inchi ID	InChI=1S/C23H27N5O5/c24-8-7-15-11-26-19-6-5-17(10-18(15)19)33-13-22(31)27-12-21(30)28-20(23(25)32)9-14-1-3-16(29)4-2-14/h1-6,10-11,20,26,29H,7-9,12-13,24H2,(H2,25,32)(H,27,31)(H,28,30)/t20-/m0/s1
PubChem CID	131670
ChEMBL	CHEMBL159174
IUPHAR	N/A
BindingDB	50286672
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor.

Experimental Data

Parameter	Value	Reference	Database source
Ki	575.43 nM	PMID7984267	BindingDB
Ki	582.0 nM	PMID8224165	BindingDB

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