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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	CHEMBL85362
Molecular formula	C15H23NO
IUPAC name	2-(dipropylamino)-2,3-dihydro-1H-inden-4-ol
Molecular weight	233.355
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.8
Synonyms	4-Hdpi 1H-Inden-4-ol, 2-(dipropylamino)-2,3-dihydro- SCHEMBL7445447 2-(Dipropylamino)indan-4-ol AC1L3U0W (R)-2-Dipropylamino-indan-4-ol 4-hydroxy-2-(di-n-propyl-amino)indan 1H-Inden-4-ol, 2-(dipropylamino)-2,3-dihydro-, (R)- 78950-86-4 2-Dipropylamino-indan-4-ol BDBM50107867 (S)-2-Dipropylamino-indan-4-ol 4-Hydroxy-2-(di-n-propylamino)indan CTK2G4697 2-(dipropylamino)-2,3-dihydro-1H-inden-4-ol 94843-89-7 [ Show all ]
Inchi Key	CJKPENGZQFFKLK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23NO/c1-3-8-16(9-4-2)13-10-12-6-5-7-15(17)14(12)11-13/h5-7,13,17H,3-4,8-11H2,1-2H3
PubChem CID	146855
ChEMBL	CHEMBL85362
IUPHAR	N/A
BindingDB	50107867
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	19.5 nM	PMID11741489	BindingDB,ChEMBL

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