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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	CHEMBL53967
Molecular formula	C21H34O3
IUPAC name	(5S,6E,8E,10E,12R,14Z)-5-hydroxy-12-methylicosa-6,8,10,14-tetraenoic acid
Molecular weight	334.5
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	BDBM50279865 (6E,8E,10E,14Z)-(5S,12R)-5-Hydroxy-12-methyl-icosa-6,8,10,14-tetraenoic acid
Inchi Key	CJHXJQVOZSVURY-XWRXVLDRSA-N
Inchi ID	InChI=1S/C21H34O3/c1-3-4-5-6-7-10-14-19(2)15-11-8-9-12-16-20(22)17-13-18-21(23)24/h7-12,15-16,19-20,22H,3-6,13-14,17-18H2,1-2H3,(H,23,24)/b9-8+,10-7-,15-11+,16-12+/t19-,20-/m1/s1
PubChem CID	44296838
ChEMBL	CHEMBL53967
IUPHAR	N/A
BindingDB	50279865
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3800.0 nM	, Bioorg. Med. Chem. Lett., (1991) 1:3:179	BindingDB,ChEMBL

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