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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	sulconazole
Molecular formula	C18H15Cl3N2S
IUPAC name	1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole
Molecular weight	397.742
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	6.1
Synonyms	Prestwick1_000810 Spectrum3_001457 Sulconazole [INN:BAN] (+-)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole AC-13116 BRD-A70649075-008-05-0 CHEBI:77776 DTXSID8044129 KBio2_007032 SBI-0051660.P002 Spectrum_001416 Sulcosyn 1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole 61318-90-9 AKOS015961204 BSPBio_002953 cid_65495 IDI1_000220 KBioSS_001896 NINDS_000220 SPBio_002600 ( -)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole AB00053607_17 BDBM31770 C18H15Cl3N2S DB06820 KBio2_001896 Prestwick2_000810 Spectrum4_000436 Sulconazolum 1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole 1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, (+-)- AC1L1K35 BRD-A70649075-008-17-5 Exelderm KBio3_002453 SCHEMBL34761 Sulconazol 1-[2,4-dichloro-beta-(4-chlorobenzylthio)phenethyl]imidazole AB00053607 API0004256 C-21661 D08535 KB-212468 LS-176163 Prestwick0_000810 Spectrum2_001422 Sulconazole (INN) (+-)-1-(2,4-Dichlor-beta-((4-chlorbenzyl)thio)phenethyl)imidazol 1-[beta-[(4-Chlorobenzyl)thio]-2,4-dichlorophenethyl]-1H-imidazole AB0010744 BPBio1_000747 CC-34587 DivK1c_000220 KBio2_004464 Prestwick3_000810 Spectrum5_001155 Sulconazolum [INN-Latin] 1-(2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]- AFNXATANNDIXLG-UHFFFAOYSA-N BSPBio_000679 CHEMBL1221 FT-0630725 KBioGR_000792 SPBio_001524 Sulconazol [INN-Spanish] ( -)-1-(2,4-Dichlor-beta-((4-chlorbenzyl)thio)phenethyl)imidazol 1-[2-(4-Chloro-benzylsulfanyl)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole AB00053607_16 AX8152129 C08076 D0X8XA KBio1_000220 NCGC00018250-02 [ Show all ]
Inchi Key	AFNXATANNDIXLG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
PubChem CID	5318
ChEMBL	CHEMBL1221
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2607.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	1873.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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