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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Mu-type opioid receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRM1
Synonym	M-OR-1 MOR-1
Disease	N/A for non-human GPCRs
Length	98
Amino acid sequence	YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProt	P97266
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4354
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL76023
Molecular formula	C25H31NO6
IUPAC name	methyl 2-[[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]oxymethyl]prop-2-enoate
Molecular weight	441.524
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	0.5
Synonyms	BDBM50000790 methyl 2-[4-cyclopropylmethyl-10,17-dihydroxy-(13R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-14-yloxymethyl]acrylate 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6beta-[2-(methoxycarbonyl)-2-propenyloxy]morphinan-3,14-diol methyl 2-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-yloxymethyl]acrylate
Inchi Key	ZLKXBHFJETUNMU-WXIYZNRCSA-N
Inchi ID	InChI=1S/C25H31NO6/c1-14(23(28)30-2)13-31-18-7-8-25(29)19-11-16-5-6-17(27)21-20(16)24(25,22(18)32-21)9-10-26(19)12-15-3-4-15/h5-6,15,18-19,22,27,29H,1,3-4,7-13H2,2H3/t18-,19-,22+,24+,25-/m1/s1
PubChem CID	10026312
ChEMBL	CHEMBL76023
IUPHAR	N/A
BindingDB	50000790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
% recovery	21.0 -	PMID1320121	ChEMBL
% recovery	59.0 -	PMID1320121	ChEMBL
% recovery	95.0 -	PMID1320121	ChEMBL
IC50	2.5 nM	PMID1335078, PMID1320121	BindingDB,ChEMBL

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