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GPCR

NameMetabotropic glutamate receptor 2
SpeciesRattus norvegicus (Rat)
GeneGrm2
Synonymglutamate receptor
GPRC1B
metabotropic glutamate receptor 2
mGlu2 receptor
mGluR2
DiseaseN/A for non-human GPCRs
Length872
Amino acid sequenceMESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtP31421
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2851
IUPHAR290
DrugBankN/A

Ligand

NameAC1MWWXC
Molecular formulaC7H14NO6P
IUPAC name2-amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid
Molecular weight239.164
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogP-4.8
SynonymsSCHEMBL4088690
2-(hydroxycarbonyl)ethyl-3-amino-3-(hydroxycarbonyl)propyl phosphinic acid
2-amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid
CHEMBL1092727
Inchi KeyCIOKCIBFBZYLCA-UHFFFAOYSA-N
Inchi IDInChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)
PubChem CID3756397
ChEMBLCHEMBL1092727
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5052000.0 nMPMID20218620ChEMBL

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