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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392150
Molecular formula	C18H13NO5
IUPAC name	4-oxo-8-[(2-phenylacetyl)amino]chromene-2-carboxylic acid
Molecular weight	323.304
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.1
Synonyms	BDBM50436033
Inchi Key	CINUWZRGRGQLJV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H13NO5/c20-14-10-15(18(22)23)24-17-12(14)7-4-8-13(17)19-16(21)9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,19,21)(H,22,23)
PubChem CID	71734945
ChEMBL	CHEMBL2392150
IUPHAR	N/A
BindingDB	50436033
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	8960.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	107.0 %	PMID23713606	ChEMBL
Ki	2720.0 nM	PMID23888932	BindingDB,ChEMBL

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