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Name | Gastrin/cholecystokinin type B receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Cckbr |
Synonym | CHOLREC Cholecystokinin-2 receptor CCK2-R CCK2 receptor CCK-BR [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG |
UniProt | P30553 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3508 |
IUPHAR | 77 |
DrugBank | N/A |
Name | CHEMBL205423 |
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Molecular formula | C28H29N7O3 |
IUPAC name | N-[3-(methylamino)phenyl]-2-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-5-pyridin-2-yl-1,3,4-benzotriazepin-3-yl]acetamide |
Molecular weight | 511.586 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | BDBM50410843 SCHEMBL3910565 |
Inchi Key | CIKVHFDOFUTQRP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H29N7O3/c1-29-20-9-8-10-21(17-20)31-25(36)18-35-28(38)34(19-26(37)33-15-6-7-16-33)24-13-3-2-11-22(24)27(32-35)23-12-4-5-14-30-23/h2-5,8-14,17,29H,6-7,15-16,18-19H2,1H3,(H,31,36) |
PubChem CID | 11699148 |
ChEMBL | CHEMBL205423 |
IUPHAR | N/A |
BindingDB | 50410843 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 1047.13 nM | PMID16570921 | BindingDB,ChEMBL |
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