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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Mus musculus (Mouse)
Gene	Htr5a
Synonym	MR22 Htr5 5HT5- 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha 5-HT5A receptor 5-HT5A 5-HT-5A 5-HT-5 Serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P30966
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3597
IUPHAR	10
DrugBank	N/A

Ligand

Name	D-Lysergic acid
Molecular formula	C16H16N2O2
IUPAC name	7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxylic acid
Molecular weight	268.316
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.0
Synonyms	6-Methyl-9,10-didehydroergoline-8-carboxylic acid-, (8.beta.)- CPD-12364 NSC_622688 AC1L9AW7 Ergoline-8-carboxylic acid, 9,10-didehydro-6-methyl-, (8.beta.)- ZAGRKAFMISFKIO-UHFFFAOYSA-N (6aR)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxylic acid C07541 L000805 82-58-6 D(+)-Lysergic acid SCHEMBL12951376 AC1LDO0Z Ergoline-8.beta.-carboxylic acid, 9,10-didehydro-6-methyl- 6-Methyl-9,10-didehydroergoline-8-carboxylic acid CAS_82-58-6 lysergate SureCN1162252 (+)-Lysergic acid BDBM82080 Indolo[4,3-fg]quinoline, ergoline-8-carboxylic acid deriv. [ Show all ]
Inchi Key	ZAGRKAFMISFKIO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H16N2O2/c1-18-8-10(16(19)20)5-12-11-3-2-4-13-15(11)9(7-17-13)6-14(12)18/h2-5,7,10,14,17H,6,8H2,1H3,(H,19,20)
PubChem CID	622688
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2000.0 nM	PMID8549774	BindingDB

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