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Name | D(2) dopamine receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Drd2 |
Synonym | D2 receptor D2(415) and D2(444) D2A and D2B D2R Dopamine D2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC |
UniProt | P61169 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL339 |
IUPHAR | 215 |
DrugBank | N/A |
Name | CHEMBL432972 |
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Molecular formula | C18H20N4 |
IUPAC name | 1-pyridin-2-yl-4-(4-pyridin-3-ylbut-3-ynyl)piperazine |
Molecular weight | 292.386 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 2.4 |
Synonyms | 1-Pyridin-2-yl-4-(4-pyridin-3-yl-but-3-ynyl)-piperazine BDBM50052527 SCHEMBL9044375 1-[4-(3-Pyridinyl)-3-butynyl]-4-(2-pyridinyl)piperazine ZINC1533800 |
Inchi Key | AFKFISMAIMRWCI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H20N4/c1-3-10-20-18(8-1)22-14-12-21(13-15-22)11-4-2-6-17-7-5-9-19-16-17/h1,3,5,7-10,16H,4,11-15H2 |
PubChem CID | 10637409 |
ChEMBL | CHEMBL432972 |
IUPHAR | N/A |
BindingDB | 50052527 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 5388.0 nM | PMID8759640 | BindingDB,ChEMBL |
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