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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Leukotriene B4 receptor 1
Species	Homo sapiens (Human)
Gene	LTB4R
Synonym	BLT1 receptor BLTR Chemoattractant receptor-like 1 G-protein coupled receptor 16 GPR16 P2Y7 P2Y purinoceptor 7 LTB4-R1 LTB4-R 1 [ Show all ]
Disease	Inflammatory disease Inflammatory bowel disease Human immunodeficiency virus infection Pancreatic cancer Psoriasis Cystic fibrosis Osteoporosis Renal cancer Rheumatoid arthritis Asthma Allergy [ Show all ]
Length	352
Amino acid sequence	MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
UniProt	Q15722
Protein Data Bank	N/A
GPCR-HGmod model	Q15722
3D structure model	This predicted structure model is from GPCR-EXP Q15722.
BioLiP	N/A
Therapeutic Target Database	T59626
ChEMBL	CHEMBL3911
IUPHAR	267
DrugBank	BE0003490

Ligand

Name	Leucettamine A
Molecular formula	C20H19N3O4
IUPAC name	4,5-bis(1,3-benzodioxol-5-ylmethyl)-1-methylimidazol-2-amine
Molecular weight	365.389
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.2
Synonyms	CHEMBL111825 147395-95-7 BDBM50042185 D0F4EL 4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-imidazol-2-ylamine
Inchi Key	CHUHMZZQHYOKBF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19N3O4/c1-23-15(7-13-3-5-17-19(9-13)27-11-25-17)14(22-20(23)21)6-12-2-4-16-18(8-12)26-10-24-16/h2-5,8-9H,6-7,10-11H2,1H3,(H2,21,22)
PubChem CID	10021742
ChEMBL	CHEMBL111825
IUPHAR	N/A
BindingDB	50042185
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	750.0 nM	PMID8383730	BindingDB,ChEMBL
IC50	4000.0 nM	PMID8383730	BindingDB,ChEMBL
IC50	4600.0 nM	PMID8383730	BindingDB,ChEMBL
Ki	1300.0 nM	PMID8383730	BindingDB,ChEMBL
Ki	3500.0 nM	PMID8230123	BindingDB,ChEMBL

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